KMID : 1202320120050020075
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Brain & NeuroRehabilitation 2012 Volume.5 No. 2 p.75 ~ p.81
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Efficacy and Safety of Solifenacin Succinate for Urinary Difficulty in Brain Lesion ?Multicenter Prospective Study?
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Bok Soo-Kyung
Lim Jun-Ho Cho Kang-Hee Choi Eun-Seok Kim Sang-Soo Lee Young-Jin Park Noh-Kyoung
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Abstract
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Objective: We studied the efficacy and safety of solifenacin for urinary difficulty in brain lesion from multicenter prospective study.
Method: Eighty patients with brain lesion who visited from 5 multicenter department of rehabilitation medicine from May 2009 to June 2010 were included. Patients were treated with solifenacin 5 mg to 10 mg for 12 weeks. The outcome measure was mean change in daily micturation frequency, daily frequency of incontinence, urgency episodes, and nocturia episodes from baseline to week 12. Patient¡¯s attitude to drug was assessed using the BSW Questionnaire (Benefit, Satisfaction and Willingness to Continue Questions).
Results: Sixty-one of 80 were evaluated for effect. All voiding parameters showed significant improvement after 12 weeks of treatment (p£¼0.05). There was no significant difference in efficacy of solifenacin between ischemic and hemorrhagic stroke. A twenty-two patients experienced 27 adverse events (AE). The most frequent AE were dry mouth (12.5%) and constipation (6.3%). Treatment related adverse events with solifenacin were mainly mild in severity, and only led to discontinuation in 6.3% of patients.
Conclusion: Solifenacin succinate improve urinary difficulty symptoms with acceptable efficacy and safety in patient with brain lesion.
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KEYWORD
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brain injuries, solifenacin succinat, urinary dysfunction
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